Congresses, conventions and excursions of group Imming


T. Rogosch, M. Kathmann, P. Imming. "Arylpropionic and arylacetic acid
derivatives as analogs of endogenous cannabinoids."
Vortrag

A. Meyer, P. Imming, "Anthemis cotula – a critical adulteration of
Matricaria recutita."
Poster

M. Ramadan, S. Goeters, P. Imming, B. Hempel, "Anti-Inflammatory
Proazulenes and Azulenes from Chamomile"
Poster

T. Buß, P. Imming, "Willow bark and its glucosides." Poster




Saxon Apothecary Museum Leipzig
February - Special exhibition "spices"

Website

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Auerbachs cellar
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spice exhibition
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on tour
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market place
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Leipzig from MDR-tower
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Close-up
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Leipzig Station
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discussions
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Guided tour
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pure knowledge
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ergot mill
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radium water
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  • June/December 2006 - Visiting Freyburg - Germany's northernmost wine-growing district

Freyburg
main station
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Castle Ruin
Neuenburg
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Famous sparkling
wine - Rotkäppchen
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Pity the one
that passes by
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View onto
Unstrut valley
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Adventurous but
appalling discoveries
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Enjoying the
Winemaker's meal
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  • January/February 2007 - Research trip to CNR Pozzuoli, Italy (by C. Sinning)

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View on Mount Vesuvius
from Naples
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View over Naples
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Golf of Pozzuoli
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Workgroups
Di Marzo
and De Petrocellis
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Entry
CNR Pozzuoli
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Liquid scintillation
counter
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  • In cooperation with Prof. Vincenzo Di Marzo and Prof. Luciano De Petrocellis at the Consiglio Nazionale Delle Ricerche (CNR, equivalent to German Max-Planck-Institute) in Pozzuoli, near Naples, we investigated synthesis products at targets of endocannabinoid system. The compounds, mostly oleic and arachidonic acid amides were tested for inhibition of fatty acid amide hydrolase (FAAH) and anandamide transporter as well as binding to cannabinoid receptors (CB1 and CB2) and vanilloid receptor 1 (TRPV1). In vitro test systems were based on 3H- or 14C-labelled substances serving as radioligands at the cannabinoid receptors or as substrate for FAAH or anandamide transporter. Data measurement was performed by liquid scintillation counting. So far we found novel ligands at CB1, CB2 and TRPV1 that showed affinity down to submicromolar range.



  • September 2007 - 55th International Congress and Annual Meeting of the Society
                                      for Medicinal Plant Research in Graz (Austria)

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view over Graz
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downtown
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"Grazer Uhrturm"
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view onto house of art
and the mur isle
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river mur
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sacher.jpg
at Café Sacher
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town hall
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a technical diskussion?
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poster session
René
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poster session
Christian
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poster session
Achim
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final dining
at the "Krebsenkeller"
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C. Oehler, P. Imming. "Synthesis of derivatives of chamazulene carboxylic acid
as potential inhibitors of inflammation via interaction with CB receptors"
Poster

A. Meyer, K. Relius, P. Imming, "Identification of alkaloids from
fumariaceous plants"
Poster

R. Schneider, M.G. Cascio, V. Di Marzo, P. Imming, "Synthesis of potential theanine
metabolites, related structures and their affinity for CB receptors"
Poster

C. Sinning, L. De Petrocellis, V. Di Marzo, P. Imming, "Potential drug metabolites
as endocannabinoids and endovanilloids"
Poster



  • Oktober/November 2007 - Research trip to University of Kuopio, Finland (by A. Meyer)

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Canthia building
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institute staff
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Metabolia lab
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Victor
platereader
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university
pharmacy
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lake scenery
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  • In cooperation with Prof. Hannu Raunio and Prof. Risto Juvonen from the institute of pharmacology and toxicology of University of Kuopio we tested 36 different isoquinoline alkaloids from natural, semi- or total synthetic origin on inhibition of Cytochrom P450 enzymes. We screened 7 out of 9 of the most important human CYP P450 enzymes namely 1A2, 2A6, 3A4, 2B6, 2C8, 2C9 and 2C19. The assays base upon recombinant supersome enzymes with fluorogenic substrates which compete with the test compounds and form a fluorescing metabolite that can easily be identified and quantified with a fluorescence platereader. As expected the alkaloids show strong inhibition of 3A4 (main enzyme for metabolism of xenobiotics), but we also found unexpectedly selective inhibition of 1A2, 2B6, 2C8 and 2C19 down to the nanomolar range.